CDC’s Division of Adolescent and School Health (DASH) has released a series of fact sheets: Adolescent Health: What Works In Schools. The series translates scientific literature and expertise about what is most likely to be effective in reducing adolescent risk for HIV infection and other STDs. The series summarizes recommended approaches and information from DASH’s evidence-based approach to school-based HIV and STD prevention. It includes providing quality sexual health education, connecting students to sexual health services, and establishing safe and supportive school environments. These evidence-based strategies benefit all students. Further, activities related to health education and health services can be tailored to address health outcomes other than sexual behaviors, including high-risk substance use, violence victimization, and mental health. Promoting safe and supportive environments can address all of these health outcomes.